Inhibition of hepatic uptake of alpha aminoisobutyric acid by ethanol: effects of pyrazole and metabolites of ethanol

Autor:	V J, Piccirillo, J W, Chambers
Rok vydání:	1976
Předmět:	Male Aminoisobutyric Acids Time Factors Ethanol Phenoxybenzamine Acetaldehyde In Vitro Techniques Rats Perfusion Liver Depression Chemical Animals Pyrazoles Amino Acids
Zdroj:	Research communications in chemical pathology and pharmacology. 13(2)
ISSN:	0034-5164
Popis:	Ethanol inhibits the uptake of AIB by the isolated perfused rat liver. However, if the metabolism of ethanol is blocked by pyrazole, there is no reduction in accumulation of AIB by the liver. Acetaldehyde and acetate, metabolites of ethanol have no effect on AIB uptake by the liver. The inhibition of urea synthesis by ethanol is also prevented by pyrazole. Neither of the metabolites of ethanol inhibit urea synthesis in the isolated liver.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::733c5c422e04682f16fb6c42d9144ded https://pubmed.ncbi.nlm.nih.gov/943817 Zobrazit plný text záznamu