Association between genetic polymorphisms and ovarian cancer risk
| Autor: | Laetitia, Delort, Nasséra, Chalabi, Samir, Satih, Nadège, Rabiau, Fabrice, Kwiatkowski, Yves-Jean, Bignon, Dominique J, Bernard-Gallon |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Ovarian Neoplasms
Arylamine N-Acetyltransferase Estrogens Catechol O-Methyltransferase Polymorphism Single Nucleotide Xenobiotics Cytochrome P-450 Enzyme System Glutathione S-Transferase pi Receptors Estrogen Case-Control Studies Cytochrome P-450 CYP1B1 Cytochrome P-450 CYP1A1 Humans Female Genetic Predisposition to Disease Aryl Hydrocarbon Hydroxylases Receptors Progesterone Alleles |
| Zdroj: | Anticancer research. 28(5B) |
| ISSN: | 0250-7005 |
| Popis: | The etiology of ovarian cancer is not fully understood. Polymorphisms in low penetrance genes involved in carcinogen and estrogen metabolism are hypothesized to play a role in the initiation of carcinogenesis.A case-control study was conducted to investigate the role of these polymorphisms in ovarian cancer risk. The participants were genotyped for eleven polymorphisms in seven genes involved in estrogen and xenobiotic metabolism (CYP1A1, CYP1B1, COMT, GSTP1, NAT2, estrogen receptor ESR, and progesterone receptor PGR).The odds ratios for ovarian cancer risk were 2.02 (95% confidence interval [CI] = 1.14-3.56) in the NAT2 intermediate acetylators and 4.07 (95% CI = 1.30-12.70) in the slow acetylators. At least three cumulative high-risk genotypes increased ovarian cancer risk, but not significantly. More studies are needed in order to define genetic ovarian risk factors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|