| Autor: |
Jie-xu, Zhang, Yan-bo, Chen, Ke-rang, Zhang, Qi, Xu, Yan, Shen |
| Rok vydání: |
2010 |
| Předmět: |
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| Zdroj: |
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 31(6) |
| ISSN: |
1000-503X |
| Popis: |
To explore the association between monoamine oxidase A (MAOA) variable number tandem repeat (VNTR) polymorphism and major depression in Chinese Han population.Polymerase chain reaction was used to genotype MAOA VNTR polymorphism. A total of 512 major depression patients and 566 normal controls were recruited in our study. These patients were also assessed using the 14-item Hamilton anxiety scale. RESULTS The allele frequency of MAOA VNTR was not significantly different between the male/female major depression patients and the normal controls. Compared with the normal controls, MAOA VNTR genotype was significantly more frequent in female major depression patients (P=0.002), but not in male patients (P=0.17). MAOA VNTR-L carrier was also associated with "fear" symptom in female patients (P=0.0056).MAOA gene is associated with the major depression in Chinese Han population, especially among female patients. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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