Hormonal enhancement of neuronal firing is linked to structural remodelling of excitatory and inhibitory synapses

Autor:	A, Parducz, Z, Hoyk, Z, Kis, L M, Garcia-Segura
Rok vydání:	2002
Předmět:	Neurons Rats Sprague-Dawley Estradiol Ovariectomy Synapses Animals Female Synaptic Transmission Rats
Zdroj:	The European journal of neuroscience. 16(4)
ISSN:	0953-816X
Popis:	The ovarian hormone estradiol induces morphological changes in the number of synaptic inputs in specific neuronal populations. However, the functional significance of these changes is still unclear. In this study, the effect of estradiol on the number of anatomically identified synaptic inputs has been assessed in the hypothalamic arcuate nucleus. The number of axo-somatic, axodendritic and spine synapses was evaluated using unbiased stereological methods and a parallel electrophysiological study was performed to assess whether synaptic anatomical remodelling has a functional consequence on the activity of the affected neurons. Estradiol administration to ovariectomized rats induced a decrease in the number of inhibitory synaptic inputs, an increase in the number of excitatory synapses and an enhancement of the frequency of neuronal firing. These results indicate that oestrogen modifications in firing frequency in arcuate neurons are temporally linked to anatomical modifications in the numerical balance of inhibitory and excitatory synaptic inputs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::72d749f5f8cf240ab64b6a5ca0d27fe4 https://pubmed.ncbi.nlm.nih.gov/12270042 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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