Non-cell autonomous control of precerebellar neuron migration by Slit and Robo proteins

Autor: Chloé, Dominici, Quentin, Rappeneau, Pavol, Zelina, Stéphane, Fouquet, Alain, Chédotal
Rok vydání: 2017
Předmět:
Zdroj: Development (Cambridge, England). 145(2)
ISSN: 1477-9129
Popis: During development, precerebellar neurons migrate tangentially from the dorsal hindbrain to the floor plate. Their axons cross it but their cell bodies stop their ventral migration upon reaching the midline. It has previously been shown that Slit chemorepellents and their receptors, Robo1 and Robo2, might control the migration of precerebellar neurons in a repulsive manner. Here, we have used a conditional knockout strategy in mice to test this hypothesis. We show that the targeted inactivation of the expression of
Databáze: OpenAIRE