| Autor: |
M, Mori, G F, Barnard, R J, Staniunas, J M, Jessup, G D, Steele, L B, Chen |
| Rok vydání: |
1993 |
| Předmět: |
|
| Zdroj: |
Oncogene. 8(10) |
| ISSN: |
0950-9232 |
| Popis: |
Prothymosin alpha (PT-alpha) is a nuclear protein involved in cell proliferation. Transcription of PT-alpha has been reported to be regulated by the c-myc gene in vitro. We identified PT-alpha as being overexpressed in a human colon cancer minus normal mucosa subtraction cDNA library. Northern blot (messenger RNA) analysis showed that both PT-alpha and c-myc genes were overexpressed in human colorectal cancers compared with adjacent normal tissues. Immunohistochemical studies for PT-alpha and c-myc supported these findings. There was no correlation between PT-alpha or c-myc messenger RNA expression and Dukes' stage of colorectal cancer; or between either of these two and actin messenger RNA expression. There was, however, a significant correlation between the PT-alpha expression and c-myc expression (P0.001). These findings support the hypothesis that PT-alpha gene transcription may be associated with, and possibly under the control of, the c-myc gene in human colorectal cancers. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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