| Autor: |
R M, Rawal, D D, Patel, B P, Patel, M M, Patel, M K, Wadhwa, P S, Patel, J M, Bhatavdekar |
| Rok vydání: |
1999 |
| Předmět: |
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| Zdroj: |
International journal of cancer. 83(6) |
| ISSN: |
0020-7136 |
| Popis: |
Serum and tumor cytosolic levels of glutathione-S-transferase (GST) and glutathione-reductase (GR) activity were determined spectrophotometrically. The levels were correlated with clinicopathological criteria and a tobacco-associated protein band (T band) found in serum. The results showed significantly decreased mean serum GST levels (p0.02) in cancer patients as compared with controls. However, mean serum GR levels were significantly higher in patients than in controls (p0.01). T-band-positive patients showed low GST and low GR activity as compared with T-band-negative patients. Tumor cytosolic-enzyme levels of GST and GR activity were significantly higher (p0.0003 and p0.0001, respectively) than in corresponding adjacent noncancerous mucosa. Tumour cytosolic GST and GR activity showed significant association with clinicopathologic criteria, e.g., stage, histologic grade and nodal involvement. T-band-negative patients showed significantly higher levels of GST (p0.0001) than did T-band-positive patients. Low levels of cytosolic GST may be associated with increased susceptibility towards carcinogen-induced damage. The results suggest that the presence of T band in the sera may be associated with a high-risk phenotype due to decreased detoxification ability. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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