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The article presents the results of evaluation of laboratory diagnostic value of relationships between the rate of detection of fragments of genes of pathogenicity islands associated with E. coli pathogenicity in clinical strains of S. enteritidis, antibiotic resistance of cultures and clinical characteristics of salmonellosis in adults. The sample included 105 patients with salmonellosis to apply the genetic test to isolated strains of S. enteritidis. The E. coli fragments of genes of pathogenicity islands are detected in 102 out of 105 analyzed strains of S. enteritidis (97.1%). The fragments specific to hlyA E. coli are detected in various qualitative and quantitative combinations in 50 (49.0%) clinical strains of S. enteritidis, hlyB--in 54 (52.9%), sfaG--in 57 (55.9%) and sfaA--in 29 (28.4%). The correlation is established between presence of fragments of genes of pathogenicity islands in S.enteritidis associated with E. coli pathogenicity and resistance to ampicillin, doxycycline, cephasoline, chloramphenicol, carbenicillin. The dependence of disease severity from S. enteridis poly-resistance to antibiotics is established. |
