| Autor: |
Eva E, Kurisinkal, Vincenzo, Caroprese, Marianna M, Koga, Diana, Morzy, Maartje M C, Bastings |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Molecules (Basel, Switzerland). 27(15) |
| ISSN: |
1420-3049 |
| Popis: |
Targeting cells specifically based on receptor expression levels remains an area of active research to date. Selective binding of receptors cannot be achieved by increasing the individual binding strength, as this does not account for differing distributions of receptor density across healthy and diseased cells. Engaging receptors above a threshold concentration would be desirable in devising selective diagnostics. Integrins are prime target candidates as they are readily available on the cell surface and have been reported to be overexpressed in diseases. Insights into their spatial organization would therefore be advantageous to design selective targeting agents. Here, we investigated the effect of activation method on integrin α |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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