| Autor: |
Chengjie, Tang, Longqiang, Shu, Yuankai, Wu, Liangjuan, Zhao, Yifan, Zhang, Yafei, Hou, Liming, Lu |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. 36(9) |
| ISSN: |
1007-8738 |
| Popis: |
Neutrophils are the most abundant circulating leukocytes in healthy adults, serving as the first-line defense against infections. In the last few years, scientists have reported neutrophils of immune suppressive properties, such as tumor-associated neutrophils (TAN) and low-density neutrophils (LDN). These neutrophils are found to be involved in many physiological and pathological conditions owing to their ability of regulating T cell functions and promoting angiogenesis and tumor growth through a number of mechanisms, including PD-1/PD-L1, antigen presentation, reactive oxygen species (ROS), arginase-1 (Arg1), inducible nitric oxide synthase (iNOS), etc. This review summarizes the recent advances in investigating the function and mechanism of immune suppressive neutrophils. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
