Complementary role of parathormone washout test to
| Autor: | Semra, Ince, Ozdes, Emer, Salih, Deveci, Kursat, Okuyucu, Engin, Alagoz, Huseyin, San, Aslı, Ayan, Ozgur, Karacalioglu, Cem, Haymana, Bengul, Gunalp, Nuri, Arslan |
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| Rok vydání: | 2017 |
| Předmět: |
Adenoma
Adult Male Parathyroidectomy Technetium Tc 99m Sestamibi Oxyphil Cells Single Photon Emission Computed Tomography Computed Tomography Biopsy Fine-Needle Reproducibility of Results Middle Aged Hyperparathyroidism Primary Sensitivity and Specificity Body Fluids Tumor Burden Parathyroid Glands Parathyroid Neoplasms Parathyroid Hormone Adenoma Oxyphilic Humans Female Radiopharmaceuticals Radionuclide Imaging Aged Ultrasonography |
| Zdroj: | Revista espanola de medicina nuclear e imagen molecular. 37(4) |
| ISSN: | 2253-8089 |
| Popis: | Parathyroid scintigraphy (PS) can be negative or equivocal (N/E) in a considerable number of cases with highly suspicious clinical findings and biochemical results for parathyroid adenoma (PA). The aims of this study were to investigate the complementary role of parathormone washout test (PWT) to PS in patients with primary hyperparathyroidism (PHPT) and evaluate histopathologic aspects of PAs in comparison with PS results.Thirty-eight patients with PHPT referred for PS were included in the study. Seventeen patients had both scintigraphic and ultrasonographic findings concordant with PA (Group A). Twenty-one patients having N/E PS, but suspected lesions for PA on ultrasonography (US) formed Group B. PWT was performed for all patients and they underwent the surgical intervention. An adenoma was removed in all patients and the histopathologic cell characteristics were established.The tumor size on US was larger in those patients whose adenomas were seen on the PS (P.001). The percentages of chief (or principal), oxyphilic and clear cells in PAs were not statistically different between the groups. Serum parathormone level and PWT were not statistically significant between Group A and Group B (P=.095 and P=.04, respectively).Although there is not a definitive threshold value, the sensitivity of PS increases with lesion size. While chief cell and oxyphilic cell content of PAs tend to deplete in N/E PS, clear cell rate increases substantially. Combining PS with both US and PWT increases the sensitivity of detection and localization of PAs. |
| Databáze: | OpenAIRE |
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