Chemoimmunotherapy for advanced gastrointestinal carcinomas

Autor:	Malvicini, Mariana, Piccioni, Flavia, Bayo, Juan, Fiore, Esteban, Atorrasagasti, Catalina, Alaniz, Laura, Garcia, Mariana, Aquino, Jorge B., Gidekel, Manuel, Matar, Pablo, Mazzolini, Guillermo
Jazyk:	angličtina
Rok vydání:	2012
Předmět:	interleukin-12 cyclophosphamide immunomodulation Author's View gene therapy advanced gastrointestinal carcinomas
Zdroj:	Oncoimmunology
ISSN:	2162-402X 2162-4011
Popis:	The combination of a single low dose of cyclophosphamide (Cy) with the adenovirus-mediated gene transfer of interleukin-12 (AdIL-12) might represent a successful therapy for experimental gastrointestinal tumors. This approach has been proven to revert immunosuppressive mechanisms elicited by cancer cells and to synergistically promote antitumor immunity. In addition, this therapeutic regimen has been shown to be more efficient in achieving complete tumor regressions in mice than the application of a metronomic schedule of Cy plus AdIL-12.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7276a6ff471376b61ca72d9eb3d8f8c3 http://europepmc.org/articles/PMC3525625 Zobrazit plný text záznamu Plný text ve formátu PDF