| Autor: |
Claudia, Hernández-Jiménez, J Raúl, Olmos-Zúñiga, Matilde, Baltazares-Lipp, Rogelio, Jasso-Victoria, Adrián, Polo-Jerez, María Teresa, Pérez-López, Luis Florentino, Vázquez-Justiniano, Néstor Emmanuel, Díaz-Martínez, Miguel, Gaxiola-Gaxiola, Laura, Romero-Romero, Axel Edmundo, Guzmán-Cedillo, Mario Enrique, Baltazares-Lipp, Juan Carlos, Vázquez-Minero, Luis Horacio, Gutiérrez-González, Marcelino, Alonso-Gómez, Mariana, Silva-Martínez |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Disease markers. 2022 |
| ISSN: |
1875-8630 |
| Popis: |
Lung transplantation requires optimization of donor's organ use through ex vivo lung perfusion (EVLP) to avoid primary graft dysfunction. Biomarkers can aid in organ selection by providing early evidence of suboptimal lungs during EVLP and thus avoid high-risk transplantations. However, predictive biomarkers of pulmonary graft function such as endothelin-converting enzyme (ECE-1) and vascular endothelial growth factor (VEGF) have not been described under EVLP with standard prolonged hypothermic preservation, which are relevant in situations where lung procurement is difficult or far from the transplantation site. Therefore, this study is aimed at quantifying ECE-1 and VEGF, as well as determining their association with hemodynamic, gasometric, and mechanical ventilatory parameters in a swine model of EVLP with standard prolonged hypothermic preservation. Using a protocol with either immediate (I-) or delayed (D-) initiation of EVLP, ECE-1 levels over time were found to remain constant in both study groups ( |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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