[Depression of respiration via toxic effects on the central nervous system following use of topical brimonidine in an infant with congenital glaucoma]

Autor:	K, Heimann, T, Peschgens, U, Merz, H, Hoernchen, T, Wenzl
Jazyk:	němčina
Rok vydání:	2007
Předmět:	Apnea Infant Newborn Glaucoma Trabeculectomy Infant Premature Diseases Cataract Postoperative Complications Brimonidine Tartrate Quinoxalines Humans Female Neurotoxicity Syndromes Ophthalmic Solutions Respiratory Insufficiency Antihypertensive Agents
Zdroj:	Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. 104(6)
ISSN:	0941-293X
Popis:	We report the case of a premature newborn (gestational age 33 weeks) with congenital glaucoma. After a trabeculotomy high intraocular pressure persisted, leading to adjuvant treatment with timolol and--when the infant was 3 weeks old--with brimonidine. After the first application of topical brimonidine the infant developed such severe apnoeic spells that intubation and temporary ventilation were necessary. A review of the literature reveals that when used in young infants brimonidine eye drops can potentially have toxic effects on the central nervous system (e.g. respiratory depression). The use of topical brimonidine is therefore not advised in this age group.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::724228b4db1f862f7e04ce9751f19ce0 https://pubmed.ncbi.nlm.nih.gov/17334744 Zobrazit plný text záznamu Full text from SpringerLink