[TFEB-amplified renal cell carcinoma. A case report and review of the literature]
| Autor: | Carlos, Mayoral Guisado, Áurea, Gómez Durán, Dixan, Agustín Benítez López, Weimar, Toro Zambrano, Alejandro, Rubio Fernández, Alicia, Moreno Ontalba, Mario, Díaz Delgado |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Chromosome Aberrations Male Oncogene Proteins Fusion Basic Helix-Loop-Helix Leucine Zipper Transcription Factors Gene Amplification Nephrectomy Kidney Neoplasms Translocation Genetic Neoplasm Proteins Diagnosis Differential Biomarkers Tumor Humans Anaplastic Lymphoma Kinase Neoplasm Metastasis Carcinoma Renal Cell In Situ Hybridization Fluorescence |
| Zdroj: | Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia. 51(4) |
| ISSN: | 1988-561X |
| Popis: | Renal carcinomas associated with translocation of transcription factors of the MiT/TFE family include, according to the latest World Health Organization classification, carcinomas with Xp11 translocation that involve the TFE3 gene and those with translocation t(6;11)(p21;q12) that affect the TFEB gene. Each one of these sub-types have well-defined clinicopathological and molecular characteristics. Currently, progress in molecular techniques has led to the description of neoplasms with molecular changes in these same genes but with alterations different to translocation. Thus, recently, cases have been published of TFEB-amplified renal carcinomas with prognoses that vary from cases associated with translocation and could therefore represent a new entity. We present a case of TFEB-amplified renal carcinoma with a full description of the clinicopathological characteristics and an updated revision of these neoplasms. |
| Databáze: | OpenAIRE |
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