| Autor: |
Torben, Biester, Thomas, Danne, Sarah, Bläsig, Kerstin, Remus, Bärbel, Aschemeier, Olga, Kordonouri, Lars, Bardtrum, Hanne, Haahr |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Pediatric diabetes. 17(8) |
| ISSN: |
1399-5448 |
| Popis: |
Insulin degludec/insulin aspart (IDegAsp) is a soluble coformulation of long-acting insulin degludec and short-acting insulin aspart. This open-label, Phase 1 study aimed to determine the pharmacodynamic and pharmacokinetic properties of IDegAsp in children (6-11 yr), adolescents (12-17 yr), and adults (18-65 yr) with type 1 diabetes mellitus (T1DM). Thirty-eight subjects received single subcutaneous IDegAsp dosing (0.5 U/kg) immediately before a standardized liquid meal (17.3 g carbohydrates/100 mL; adjusted for body weight) followed by plasma glucose (PG) and pharmacokinetic blood sampling for 36 and 57 h, respectively. There were no apparent differences between age groups in PG lowering effect (AUC |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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