Hippocampal volume, FKBP5 genetic risk alleles, and childhood trauma interact to increase vulnerability to chronic multisite musculoskeletal pain

Autor:	Jarred J, Lobo, Lizbeth J, Ayoub, Massieh, Moayedi, Sarah D, Linnstaedt
Rok vydání:	2021
Předmět:	Tacrolimus Binding Proteins Adverse Childhood Experiences Musculoskeletal Pain Humans Chronic Pain Hippocampus Polymorphism Single Nucleotide Alleles
Zdroj:	Scientific reports. 12(1)
ISSN:	2045-2322
Popis:	Chronic multisite musculoskeletal pain (CMP) is common and highly morbid. However, vulnerability factors for CMP are poorly understood. Previous studies have independently shown that both small hippocampal brain volume and genetic risk alleles in a key stress system gene, FKBP5, increase vulnerability for chronic pain. However, little is known regarding the relationship between these factors and CMP. Here we tested the hypothesis that both small hippocampal brain volume and FKBP5 genetic risk, assessed using the tagging risk variant, FKBP5rs3800373, increase vulnerability for CMP. We used participant data from 36,822 individuals with available genetic, neuroimaging, and chronic pain data in the UK Biobank study. Although no main effects were observed, the interaction between FKBP5 genetic risk and right hippocampal volume was associated with CMP severity (β = -0.020, p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::71f9833f571c58acdf20d1c826423387 https://pubmed.ncbi.nlm.nih.gov/35444168 Zobrazit plný text záznamu Full text from SpringerLink