Synthesis and biological screening of some novel amidocarbamate derivatives of ketoprofen

Autor:	Prasanta Kumar, Sahoo, Pritishova, Behera
Rok vydání:	2009
Předmět:	Biphenyl Compounds Lipoxygenase DNA Viruses Drug Evaluation Preclinical Free Radical Scavengers Quinolones Cytostatic Agents Antiviral Agents Cell Line Linoleic Acid Inhibitory Concentration 50 Picrates RNA Viruses Carbamates Lipid Peroxidation Lipoxygenase Inhibitors Soybeans
Zdroj:	European journal of medicinal chemistry. 45(7)
ISSN:	1768-3254
Popis:	A series of novel ketoprofen derivatives 4a-j bearing both amide and carbamate functionalities were prepared using benzotriazole. Selective reduction of ketoprofen produced hydroxy derivative 2, which reacts with one or 2 mol of 1-benzotriazole carboxylic acid chloride (1) gave benzotriazole derivatives 3a and 3b respectively. Antioxidative screenings revealed that the prepared compounds 3b and 4a-j possess excellent lipid peroxidation inhibition at 0.1 mM concentration. Two of the compounds 3b and 4 g also showed high soybean lipoxygenase inhibition activity, where as the amidocarbamate derivatives of ketoprofen showed only weak reducing activity against 1,1-diphenyl-2-picrylhydrazyl radicals. No selective antiviral effects were noted for the tested compounds against a broad variety of DNA and RNA viruses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::71d8efd9bff9d3fccd9ea8b0f50f6a2b https://pubmed.ncbi.nlm.nih.gov/22355807 Zobrazit plný text záznamu Full Text from ScienceDirect