Effect of the meglitinide analog S21403 on cationic fluxes and insulin release in perifused rat pancreatic islets exposed to a high concentration of D-glucose

Autor:	K, Louchami, H, Jijakli, W J, Malaisse
Rok vydání:	1999
Předmět:	Indoles Calcium Radioisotopes Isoindoles Rubidium Rats Perfusion Islets of Langerhans Glucose Cations Insulin Secretion Animals Hypoglycemic Agents Insulin Calcium Female Rats Wistar Rubidium Radioisotopes
Zdroj:	Pharmacological research. 40(3)
ISSN:	1043-6618
Popis:	The effect of the meglitinide analog S21403 (10 microm) upon(86)Rb and(45)Ca outflow and insulin release was investigated in perifused rat islets exposed to a high concentration of D-glucose (16.7 mm) in order to simulate the situation found in diabetic patients. Under these conditions, S21403 provoked a rapid, sustained and rapidly reversible increase in(86)Rb outflow, (45)Ca efflux and insulin release. These effects were suppressed or reversed when the experiments were conducted in the absence of extracellular Ca2+. They support the view that S21043 could be used as a novel insulinotropic tool in the treatment of non-insulin-dependent diabetes mellitus, the cationic and secretory responses to the drug displaying a favourable time course for prompt and not unduly prolonged activation of islet B-cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::71bb8a9eecdd88b3f47c580cae1a8b8e https://pubmed.ncbi.nlm.nih.gov/10479476 Zobrazit plný text záznamu Full Text from ScienceDirect