| Autor: |
Hongmei, Li, Jeremy P, Scott, Cheng-yi, Chen, Michel, Journet, Kevin, Belyk, Jaume, Balsells, Birgit, Kosjek, Carl A, Baxter, Gavin W, Stewart, Christopher, Wise, Mahbub, Alam, Zhiguo Jake, Song, Lushi, Tan |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Organic letters. 17(6) |
| ISSN: |
1523-7052 |
| Popis: |
A practical asymmetric synthesis of the complex fused bis-macrocyclic HCV protease inhibitor MK-6325 (1) is described. Through the combination of a high yielding and low catalyst loading ring-closing metathesis (RCM) to forge the 15-membered macrocycle with an intramolecular sp(2)-sp(3) Suzuki-Miyaura cross-coupling to append the 18-membered macrocycle, multikilogram access to the unique and challenging architecture of MK-6325 (1) has been achieved. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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