Divergent clonal differentiation trajectories of T cell exhaustion

Autor:	Bence, Daniel, Kathryn E, Yost, Sunnie, Hsiung, Katalin, Sandor, Yu, Xia, Yanyan, Qi, Kamir J, Hiam-Galvez, Mollie, Black, Colin, J Raposo, Quanming, Shi, Stefanie L, Meier, Julia A, Belk, Josephine R, Giles, E John, Wherry, Howard Y, Chang, Takeshi, Egawa, Ansuman T, Satpathy
Rok vydání:	2021
Předmět:	Mice Lymphocytes Tumor-Infiltrating Virus Diseases Receptors Antigen T-Cell Humans Animals Cell Differentiation CD8-Positive T-Lymphocytes
Zdroj:	Nature immunology. 23(11)
ISSN:	1529-2916
Popis:	Chronic antigen exposure during viral infection or cancer promotes an exhausted T cell (Tex) state with reduced effector function. However, whether all antigen-specific T cell clones follow the same Tex differentiation trajectory remains unclear. Here, we generate a single-cell multiomic atlas of T cell exhaustion in murine chronic viral infection that redefines Tex phenotypic diversity, including two late-stage Tex subsets with either a terminal exhaustion (Tex
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::71ad098f260d45a98a032770b095053f https://pubmed.ncbi.nlm.nih.gov/36289450 Zobrazit plný text záznamu Full text from SpringerLink