Hybrid tracers for sentinel node biopsy
| Autor: | N S, Van Den Berg, T, Buckle, G I, Kleinjan, W M, Klop, S, Horenblas, H G, Van Der Poel, R A, Valdés-Olmos, F I, Van Leeuwen |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Image-Guided Biopsy
Male Tomography Emission-Computed Single-Photon Evidence-Based Medicine Sentinel Lymph Node Biopsy Contrast Media Reproducibility of Results Multimodal Imaging Sensitivity and Specificity Microscopy Fluorescence Lymphatic Metastasis Neoplasms Humans Female Lymph Nodes Radiopharmaceuticals Fluorescent Dyes |
| Zdroj: | The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of.... 58(2) |
| ISSN: | 1824-4785 |
| Popis: | Conventional sentinel node (SN) mapping is performed by injection of a radiocolloid followed by lymphoscintigraphy to identify the number and location of the primary tumor draining lymph node(s), the so-called SN(s). Over the last decade research has focused on the introduction of new imaging agents that can further aid (surgical) SN identification. Different tracers for SN mapping, with varying sizes and isotopes have been reported, most of which have proven their value in a clinical setting. A major challenge lies in transferring this diagnostic information obtained at the nuclear medicine department to the operating theatre thereby providing the surgeon with (image) guidance. Conventionally, an intraoperative injection of vital blue dye or a fluorescence dye is given to allow intraoperative optical SN identification. However, for some indications, the radiotracer-based approach remains crucial. More recently, hybrid tracers, that contain both a radioactive and fluorescent label, were introduced to allow for direct integration of pre- and intraoperative guidance technologies. Their potential is especially high when they are used in combination with new surgical imaging modalities and navigation tools. Next to a description of the known tracers for SN mapping, this review discusses the application of hybrid tracers during SN biopsy and how the introduction of these new techniques can further aid in translation of nuclear medicine information into the operating theatre. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|