Herpes zoster as a risk factor for osteoporosis

Autor:	Wu, Chieh-Hsin, Chai, Chee-Yin, Tung, Yi-Ching, Lu, Ying-Yi, Su, Yu-Feng, Tsai, Tai-Hsin, Tzou, Rong-Dar, Lin, Chih-Lung
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	Adult Male Herpesvirus 3 Human Incidence Taiwan Observational Study herpes zoster Middle Aged osteoporosis Risk Assessment Young Adult Risk Factors Population Surveillance Humans Female nationwide population-based study Research Article Follow-Up Studies Forecasting Retrospective Studies
Zdroj:	Medicine
ISSN:	1536-5964 0025-7974
Popis:	The objective of this study was to investigate the risk of osteoporosis in patients with herpes zoster (HZ) infection using a nationwide population-based dataset. The Taiwan National Health Insurance Research Database was used to compare data between 11,088 patients aged 20 to 49 years diagnosed with HZ during 1996 to 2010 and a control group of 11,088 patients without HZ. Both cohorts were followed up until the end of 2010 to measure the incidence of osteoporosis. Cox proportional-hazards regression and Kaplan–Meier analyses were used to calculate hazard ratio and cumulative incidences of osteoporosis, respectively. The overall risk of osteoporosis was 4.55 times greater in the HZ group than in the control group (2.48 vs. 0.30 per 1000 person-years, respectively) after adjusting for age, gender, Charlson Comorbidity Index, and related comorbidities. Compared with controls, patients with HZ and subsequent postherpetic neuralgia had a 4.76-fold higher likelihood of developing osteoporosis (95% confidence interval: 2.44–9.29), which was a statistically significant difference (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::71819d81f6f94a0954959e08afb68b99 http://europepmc.org/articles/PMC4998325 Zobrazit plný text záznamu