| Autor: |
H J, Schnitzerling, J, Nolan |
| Rok vydání: |
1985 |
| Předmět: |
|
| Zdroj: |
Journal - Association of Official Analytical Chemists. 68(1) |
| ISSN: |
0004-5756 |
| Popis: |
A method has been developed for determining ivermectin in 5 mL samples of cattle blood by a 2-step process: cleanup solvent extraction followed by direct injection onto a normal phase liquid chromatography (LC) system with UV detection. Recovery was 77-80% +/- 5.5% standard deviation. Endogenous interference that may be present caused the lower limit of detection to be set at 4-5 ng/mL. The method was used to show that in blood the distribution of ivermectin favors plasma in a fixed proportion over cellular material, and further to provide a time-course profile of ivermectin in the whole blood of injected cattle. In whole blood, ivermectin concentration peaked between 3 and 5 days and dissipated slowly with a half-life of 3 days. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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