| Autor: |
Wioleta, Cieslik, Joanna, Szczepaniak, Anna, Krasowska, Robert, Musiol |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
Molecules |
| ISSN: |
1420-3049 |
| Popis: |
Styrylquinolines are heterocyclic compounds that are known for their antifungal and antimicrobial activity. Metal complexation through hydroxyl groups has been claimed to be a plausible mechanism of action for these types of compounds. A series of novel structures with protected hydroxyl groups have been designed and synthesized to verify the literature data. Their antifungal activity against wild-type Candida albicans strain and mutants with silenced efflux pumps activity has been determined. Combinations with fluconazole revealed synergistic interactions that were dependent on the substitution pattern. These results open a new route for designing active antifungal agents on a styrylquinoline scaffold. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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