Traditional Chinese Medicine (TCM) in the treatment of viral infections: Efficacies and mechanisms

Autor: Huang, Kai, Zhang, Pan, Zhang, Zhenghao, Youn, Ji Youn, Zhang, Hongchun, Cai, Hua Linda
Jazyk: angličtina
Rok vydání: 2021
Předmět:
PTGS2
Prostaglandin-endoperoxide synthase 2

TFs
transcription factors

CT
computerized tomography

DAVID
Database for Annotation
Visualization
and Integrated Discovery

MAPK
Mitogen-activated protein kinase

CVA
cough variant asthma

SIRS
systematic inflammatory response syndrome

Nrf2
nuclear factor erythroid 2-related factor 2

SOCS1
suppressor of cytokine signaling 1

Akt
Protein kinase B

3CLpro
Coronavirus 3-chymotrypsin-like protease

TNF-α
Tumor Necrosis Factor Alpha

HIF-1
Hypoxia-Inducible Factor-1

PI3K
Phosphoinositide 3-kinase

UPLC-DAD-QTOF-MS
Ultra performance liquid chromatography coupled with diode-array detector and quadrupole time-of-flight mass spectrometry

Medicine
Chinese Traditional

RCT
randomized controlled trial

COVID-19
Coronavirus disease 2019

S protein
SARS-CoV-2 spike (S) glycoprotein

TCM
Traditional Chinese Medicine

ACE2
angiotensin converting enzyme 2

Traditional Chinese Medicine (TCM)
HSP90AB1
Heat shock protein HSP 90-beta

ICU
intensive care unit

PCT
procalcitonin

PPARG
peroxisome proliferator-activated receptor gamma

Virus Diseases
CRP
C-reactive protein

XBJ
Xuebijing

Lung Cleansing and Detoxifying Decoction (LCDD)
IC50
50% inhibitory concentration

WBC
white blood cell

Xuebijing (XBJ)
NCOA2
Nuclear receptor coactivator 2

NFkB
Nuclear factor kappa B

PTGS1
Prostaglandin-endoperoxide synthase 1

JHQG
Jinhua Qinggan granules

KEGG
Kyoto Encyclopedia of Genes and Genomes

Article
WHO
World Health Organization

CASP3
Caspase 3

PPI
protein-protein interaction

TCMID
Traditional Chinese Medicine Integrated Database

COX-2
Cyclooxygenase-2

ROS
reactive oxygen species

ARDS
Acute respiratory distress syndrome

HSBD
Huashibaidu granules

Humans
CCL2
C-C Motif Chemokine Ligand 2

Huashibaidu granules (HSBD)
Coronavirus 3-chymotrypsin-like protease (3CLpro)
IL-6
Interleukin-6

HNF4A
hepatocyte nuclear factor 4 alpha

GO
gene ontology

HXZQ
Huoxiang Zhengqi dropping pills

ESR
erythrocyte sedimentation rate

Viral infections
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2

XFBD
Xuanfeibaidu granules

SARS-CoV-2
IP-10
Interferon gamma-induced protein 10

LCDD
Lung Cleansing and Detoxifying Decoction

COVID-19
BCL2
B-cell lymphoma 2

EGFR
epidermal growth factor receptor

HSP90AA1
Heat shock protein HSP 90-alpha

TP53
Tumor protein p53

COVID-19 Drug Treatment
Lianhua Qingwen capsules (LHQW)
COVID
Coronavirus disease

Angiotensin converting enzyme 2 (ACE2)
Interleukin-6 (IL-6)
miRNAs
micro RNAs

LHQW
Lianhua Qingwen capsules

NOS2
Nitric Oxide Synthase 2 (inducible Nitric Oxide Synthase/iNOS)

MCP-1
Monocyte Chemoattractant Protein-1

AGE-RAGE
Advanced glycation end products-Receptor for AGE

Xuanfeibaidu granules (XFBD)
IFN-γ
Interferon gamma

Jinhua Qinggan granules (JHQG)
Zdroj: Pharmacology & Therapeutics
ISSN: 1879-016X
0163-7258
Popis: COVID-19 has remained an uncontained, worldwide pandemic. While battling for the disease in China, six Traditional Chinese Medicine (TCM) recipes have been shown to be remarkably effective for treating patients with COVID-19. The present review discusses principles of TCM in curing infectious disease, and clinical evidence and mechanisms of the 6 most effective TCM recipes used in treating COVID-19 in 92% of all of the confirmed cases in China. Applications of TCM and specific recipes in the treatment of other viral infections, such as those caused by SARS-CoV, MERS-CoV, hepatitis B virus, hepatitis C virus, influenza A virus (including H1N1 and H7N9), influenza B, dengue virus as well as Ebola virus, are also discussed. Among the 6 TCM recipes, Jinhua Qinggan (JHQG) granules and Lianhua Qingwen (LHQW) capsules are recommended during medical observation; Lung Cleansing and Detoxifying Decoction (LCDD) is recommended for the treatment of both severe and non-severe patients; Xuanfeibaidu (XFBD) granules are recommended for treating moderate cases; while Huashibaidu (HSBD) and Xuebijing (XBJ) have been used in managing severe cases effectively. The common components and the active ingredients of the six TCM recipes have been summarized to reveal most promising drug candidates. The potential molecular mechanisms of the active ingredients in the six TCM recipes that target ACE2, 3CLpro and IL-6, revealed by molecular biological studies and/or network pharmacology prediction/molecular docking analysis/visualization analysis, are fully discussed. Therefore, further investigation of these TCM recipes may be of high translational value in revealing novel targeted therapies for COVID-19, potentially via purification and characterization of the active ingredients in the effective TCM recipes.
Databáze: OpenAIRE