| Autor: |
Samuel, Alsén, Jakob, Cervin, Yaxiong, Deng, Louis, Szeponik, Ulf Alexander, Wenzel, Joakim, Karlsson, Helena, Cucak, Megan, Livingston, David, Bryder, Qianjin, Lu, Bengt, Johansson-Lindbom, Ulf, Yrlid |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Frontiers in immunology. 13 |
| ISSN: |
1664-3224 |
| Popis: |
B cells interact with T follicular helper (Tfh) cells in germinal centers (GCs) to generate high-affinity antibodies. Much less is known about how cognate T-B-cell interactions influence Th cells that enter circulation and peripheral tissues. Therefore, we generated mice lacking MHC-II expressing B cells and, by thoracic duct cannulation, analyzed Th cells in the efferent lymph at defined intervals post-immunization. Focusing on gut-draining mesenteric lymph nodes (MLNs), we show that antigen-specific α |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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