Possible involvement of β₁ receptors in various emetogen-induced increases in salivary amylase activity in rats
| Autor: | Hideo, Fukui, Yoshimi, Suyama, Takako, Iwachido, Eri, Miwa |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Apomorphine Metoclopramide Isoproterenol Adrenergic beta-Agonists Adrenergic beta-1 Receptor Antagonists Propranolol Butoxamine Rats Atenolol Adrenergic beta-2 Receptor Antagonists Depression Chemical Amylases Animals Antiemetics Cisplatin Rats Wistar Receptors Adrenergic beta-1 Emetics Lithium Chloride Saliva |
| Zdroj: | Journal of pharmacological sciences. 115(1) |
| ISSN: | 1347-8648 |
| Popis: | We investigated the inhibitory effects of β₁- or β₂-adrenoceptor (AR) antagonists on salivary amylase secretion produced by various emetic agents, such as cisplatin, apomorphine, and lithium chloride (LiCl), or the non-emetic agent β(½)-AR agonist isoprenaline in rats. We also determined the inhibitory effect of metoclopramide, a dopamine D₂-receptor antagonist, on increases in the salivary amylase activity induced by apomorphine or granisetron, a 5-HT(3)-receptor antagonist, on LiCl-induced increased salivary amylase activity. Isoprenaline (0.01 mg/kg, s.c.) produced an increase in salivary amylase and the increase was inhibited by the β(½)-AR antagonist propranolol (5 mg/kg, s.c.) and β₁-AR antagonist atenolol (2 mg/kg, s.c.) but not by the β₂-AR antagonist butoxamine (8 mg/kg, s.c.). The increased amylase activity induced by cisplatin (15 mg/kg, i.v.), apomorphine (3 mg/kg, s.c.), or LiCl (120 mg/kg, i.p.) was inhibited significantly by atenolol (2 mg/kg, s.c.) but not by butoxamine (8 mg/kg, s.c.). In addition, increases in amylase activities induced by apomorphine and LiCl were inhibited significantly by metoclopramide (10 mg/kg, i.v.) and granisetron (3 mg/kg, i.v.), respectively. These results suggest that salivary amylase secretion induced by various emetogens is involved in β₁-adrenoceptor activity and that salivary amylase activity is useful to detect emetogens with no direct β₁-AR activation in rats, a species that does not exhibit vomiting. |
| Databáze: | OpenAIRE |
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