RS-33295-198: a novel, potent modulator of P-glycoprotein-mediated multidrug resistance
| Autor: | D L, Slate, N A, Bruno, S M, Casey, N, Zutshi, L J, Garvin, H, Wu, J R, Pfister |
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| Rok vydání: | 1995 |
| Předmět: |
Paclitaxel
Leukemia P388 Transplantation Heterologous Mice Nude Antineoplastic Agents Drug Synergism Sarcoma Dibenzocycloheptenes Drug Resistance Multiple Cell Line Mice Cricetulus Doxorubicin Vincristine Cricetinae Quinolines Animals ATP Binding Cassette Transporter Subfamily B Member 1 Cell Division Etoposide |
| Zdroj: | Anticancer research. 15(3) |
| ISSN: | 0250-7005 |
| Popis: | A novel multidrug resistance modulator, RS-33295-198, circumvented drug resistance in human, mouse, and Chinese hamster cell lines overexpressing P-glycoprotein. It enhanced the antiproliferative activity of doxorubicin, vincristine, etoposide, and paclitaxel and increased doxorubicin retention in multidrug-resistant hamster CHRC5 cells. RS-33295-198 modulated doxorubicin resistance in a murine P388/ADR leukemia model when administered ip via continuous minipump delivery, ip by bolus injection, and orally; it also improved the efficacy of vincristine toward P388/VCR leukemia when given ip or po. RS-33295-198 showed weak activity in enhancing doxorubicin efficacy against a multidrug-resistant human sarcoma xenograft. |
| Databáze: | OpenAIRE |
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