| Autor: |
Masato, Mashimo, Yukari, Iwasaki, Shoko, Inoue, Shoko, Saito, Koichiro, Kawashima, Takeshi, Fujii |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
Life sciences. 172 |
| ISSN: |
1879-0631 |
| Popis: |
T lymphocytes synthesize acetylcholine (ACh) and express muscarinic and nicotinic ACh receptors (mAChR and nAChR, respectively) responsible for increases in the intracellular CaMOLT-3 human leukemic cell line and murine splenocytes were loaded with fura-2 to monitor [CaT lymphocytes constitutively produce sufficient amounts of ACh to elicit autocrine changes in [CaHere, we confirmed that T lymphocytes utilize ACh as a tool to interact with each other and that autocrine ACh-activated nAChRs are involved in cytokine release and cell proliferation. These findings suggest the possibility that nAChR agonists and antagonists and smoking are able to modulate immune function, which in turn suggests the therapeutic potential of immune activation or suppression using nAChR agonists or antagonists. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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