Electrochemical [11C]CO2 to [11C]CO conversion for PET imaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7cc00319f Click here for additional data file

Autor: Anders, David A., Bongarzone, Salvatore, Fortt, Robin, Gee, Antony D., Long, Nicholas J.
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Chemical Communications (Cambridge, England)
ISSN: 1364-548X
1359-7345
Popis: Development of a novel electrochemical radiochemistry methodology i.e. reduction of [11C]CO2 to [11C]CO at room temperature and pressure using metal cyclam complexes.
The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [11C]CO from [11C]CO2. Produced [11C]CO was subsequently converted to [11C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%.
Databáze: OpenAIRE