Electrochemical [11C]CO2 to [11C]CO conversion for PET imaging† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7cc00319f Click here for additional data file
| Autor: | Anders, David A., Bongarzone, Salvatore, Fortt, Robin, Gee, Antony D., Long, Nicholas J. |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Chemical Communications (Cambridge, England) |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | Development of a novel electrochemical radiochemistry methodology i.e. reduction of [11C]CO2 to [11C]CO at room temperature and pressure using metal cyclam complexes. The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [11C]CO from [11C]CO2. Produced [11C]CO was subsequently converted to [11C]N-benzylbenzamide under mild conditions with a radiochemical purity (RCP) of >98%. |
| Databáze: | OpenAIRE |
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