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Thirty-three N (3)-2-, -3- or -4-substituted aryl-N (1)-(alkyl/aryl/substituted aryl)-triazene N (1)-oxides were synthesized and evaluated for their anticonvulsant and monoamine oxidase (MAO) inhibitory activities. Most of the compounds exhibited MAO inhibitory activity in vitro, and kinetic studies conducted with N (3)-4-chlorophenyl-N (1)-methyltriazene N (1)-oxide, the most potent inhibitor, showed that the inhibition is non-competitive in nature. The MAO inhibiting activity of the compounds correlated well with their anticonvulsant effect against maximal electroshock-induced seizures in rats. Acute toxicity studies indicate that the compounds have a wide margin of safety. |
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