Cannabinoid type 1 receptor antagonism ameliorates harmaline-induced essential tremor in rat

Autor:	Hassan, Abbassian, Benjamin J, Whalley, Vahid, Sheibani, Mohammad, Shabani
Rok vydání:	2016
Předmět:	Male Receptor Cannabinoid CB1 Essential Tremor Animals Rats Wistar Harmaline Cannabinoid Receptor Antagonists Research Papers Rats
Zdroj:	British journal of pharmacology. 173(22)
ISSN:	1476-5381
Popis:	Essential tremor (ET) is a neurological disorder with unknown aetiology. Its symptoms include cerebellar motor disturbances, cognitive and personality changes, hearing and olfactory deficits. Hyperactivity of excitotoxic cerebellar climbing fibres may underlie essential tremor and has been induced in rodents by systemic harmaline administration. Cannabinoid (CB) receptor agonists can cause motor disturbances; although, there are also anecdotal reports of therapeutic benefits of cannabis in motor disorders. We set out to establish the effects of CB receptor agonism and antagonism on an established rodent model of ET using a battery of accepted behaviour assays in order to determine the risk and therapeutic potential of modulating the endocannabinoid system in ET.Behavioural effects of systemic treatment with a CB receptor agonist (0.1, 0.5 and 1 mg kgOverall, harmaline induced robust tremor that was typically worsened across the measured behavioural domains by CB receptor agonism but ameliorated by CBThese results provide the first evidence of the effects of modulating the endocannabinoid system on motor function in the harmaline model of ET. Our data suggest that CB
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::709b5736be22c71de70f713e02f4e78d https://pubmed.ncbi.nlm.nih.gov/27545646 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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