| Autor: |
C, Ye, C L, Ho-Pao, M, Kanazirska, S, Quinn, K, Rogers, C E, Seidman, J G, Seidman, E M, Brown, P M, Vassilev |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
Journal of neuroscience research. 47(5) |
| ISSN: |
0360-4012 |
| Popis: |
The amyloid-beta peptides (A beta) are produced in excess in Alzheimer's disease (AD) and may contribute to neuronal dysfunction and degeneration. This study provides strong evidence for a novel cellular target for the actions of A beta, the phospholipase C-coupled, extracellular Ca(2+)-sensing receptor (CaR). We demonstrate that A beta(s) produce a CaR-mediated activation of a Ca(2+)-permeable, nonselective cation channel (NCC), probably via elevation in cytosolic Ca2+ (Cai), in cultured hippocampal pyramidal neurons from normal rats and from wild type mice but not those from mice with targeted disruption of the CaR gene (CaR -/-). A beta(s) also activate NCC in CaR-transfected but not in nontransfected human embryonic kidney (HEK293) cells. Thus aggregates of A beta deposited on hippocampal neurons in AD could appropriately activate the CaR, stimulating Ca(2+)-permeable channels and causing sustained elevation of Cai with resultant neuronal dysfunction. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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