Impact of the catechol-O-methyltransferase Val158Met polymorphism on the pharmacokinetics of L-dopa and its metabolite 3-O-methyldopa in combination with entacapone

Autor:	Joe, Yamamoto, Tomohiro, Omura, Sachiko, Kasamo, Shota, Yamamoto, Masayoshi, Kawata, Atsushi, Yonezawa, Yosuke, Taruno, Hisako, Endo, Hitoshi, Aizawa, Nobukatsu, Sawamoto, Kazuo, Matsubara, Ryosuke, Takahashi, Yoshikazu, Tasaki
Rok vydání:	2020
Předmět:	Antiparkinson Agents Levodopa Cross-Over Studies Nitriles Catechols Catechol O-Methyltransferase Inhibitors Humans Tyrosine Catechol O-Methyltransferase
Zdroj:	Journal of neural transmission (Vienna, Austria : 1996). 128(1)
ISSN:	1435-1463
Popis:	In the pharmacotherapy of patients with Parkinson's disease (PD), entacapone reduces the peripheral metabolism of L-dopa to 3-O-methyldopa (3-OMD), thereby prolonging the half-life (t
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::7016b08dc103d7e5e3d2f0ed69dec4f3 https://pubmed.ncbi.nlm.nih.gov/33136226 Zobrazit plný text záznamu Full text from SpringerLink