[The dynamics of the griseofulvin levels in the blood and skin of guinea pigs during its combined use with alpha-tocopherol]

Autor:	A P, Lashmanova, O G, Omel'chenko, V G, Akimov
Rok vydání:	1990
Předmět:	Time Factors Suspensions Guinea Pigs Animals Vitamin E Drug Interactions Drug Therapy Combination Griseofulvin Skin
Zdroj:	Vestnik dermatologii i venerologii. (9)
ISSN:	0042-4609
Popis:	Experiments with 120 guinea pigs have revealed that skin griseofulvin levels depend on blood griseofulvin level and reduce after a prolonged (for 3-4 weeks) administration of the antibiotic in a dose of 30 mg/kg. Reduction of P-450 system enzymes activities achieved with alpha-tocopherol slows down griseofulvin biotransformation rate and significantly elevates its blood serum and skin concentrations.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6fdc35f44597495b2e20570a08efb841 https://pubmed.ncbi.nlm.nih.gov/2284849 Zobrazit plný text záznamu