[Frequency of sex chromosome nondisjunction as affected by microtubule destabilization and heat shock in various lines of Drosophila melanogaster]

Autor:	P Ia, Shvartsman, O A, Isaenko
Rok vydání:	1999
Předmět:	Drosophila melanogaster Oogenesis Sex Chromosomes Nondisjunction Genetic Species Specificity Animals Mitosis Female Colchicine Vinblastine Microtubules Griseofulvin Heat-Shock Response
Zdroj:	Genetika. 35(7)
ISSN:	0016-6758
Popis:	Vinblastine (Vb), a drug belonging to a group of mitotic poisons, was shown to induce sexual chromosome nondisjunction and loss (SCNL) in oogenesis of different strains of Drosophila melanogaster. Heat shock (37 degrees C, 45 min) decreases the frequency of these events. The highest level of nondisjunction was demonstrated in the temperature-sensitive strain both after heat shock and Vb treatment. No increase of SCNL frequency in oocytes of females treated with griseofulvin (Gf) and Colchicine (Cl), analogues of Vb.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6fd58e478a09ba9f7ffbf523b8727813 https://pubmed.ncbi.nlm.nih.gov/10519067 Zobrazit plný text záznamu