[The effect of the new amino acid-containing 1,4-dihydropyridine glutapyrone on penicillin-induced focal epileptic activity and convulsions induced by bicuculline and thiosemicarbazide]

Autor:	M N, Karpova, O K, Germane, O Iu, Pankov, V E, Klusha, G Ia, Dubur
Rok vydání:	1993
Předmět:	Male Dihydropyridines Mice Inbred ICR Drug Evaluation Preclinical Convulsants Penicillins Bicuculline Rats Semicarbazides Disease Models Animal Mice Glutamates Seizures Animals Anticonvulsants Epilepsies Partial Rats Wistar
Zdroj:	Biulleten' eksperimental'noi biologii i meditsiny. 116(10)
ISSN:	0365-9615
Popis:	The experiments on focal penicillin-induced epileptic activity in the brain cortex (Wistar rats) and bicuculline- and thiosemicarbazide-induced seizures (Icr:Icl mice) showed that the glutapyrone possessed a significant antiepileptic activity. As previously shown, that glutapyrone has an influence on 45Ca2+ uptake by rat cortical synaptosomes (evoked by K+ depolarization) as compared with nifedipine and nimodipine, and it was effective in pentylenetetrazol-induced seizures in rats and mice. The mechanism of action of convulsants is associated with the disturbance of different links of GABAergic inhibition. It is suggested that the antiepileptic effects of glutapyrone are realized at least in part by the participation of GABAergic system.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6fbbbda5be4e8a88238d1287c84f4ed8 https://pubmed.ncbi.nlm.nih.gov/8117948 Zobrazit plný text záznamu