| Autor: |
Calum C, Bain, Christopher D, Lucas, Adriano G, Rossi |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International review of cell and molecular biology. 367 |
| ISSN: |
1937-6448 |
| Popis: |
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the largest global pandemic in living memory, with between 4.5 and 15M deaths globally from coronavirus disease 2019 (COVID-19). This has led to an unparalleled global, collaborative effort to understand the pathogenesis of this devastating disease using state-of-the-art technologies. A consistent feature of severe COVID-19 is dysregulation of pulmonary macrophages, cells that under normal physiological conditions play vital roles in maintaining lung homeostasis and immunity. In this article, we will discuss a selection of the pivotal findings examining the role of monocytes and macrophages in SARS-CoV-2 infection and place this in context of recent advances made in understanding the fundamental immunobiology of these cells to try to understand how key homeostatic cells come to be a central pathogenic component of severe COVID-19 and key cells to target for therapeutic gain. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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