| Autor: |
Lesly A, Dossett, Eric M, Toloza, Jacques, Fontaine, Lary A, Robinson, Damon, Reed, Mihaela, Druta, Douglas G, Letson, Jonathan S, Zager, Ricardo J, Gonzalez |
| Rok vydání: |
2015 |
| Předmět: |
|
| Zdroj: |
Journal of surgical oncology. 112(1) |
| ISSN: |
1096-9098 |
| Popis: |
Pulmonary metastasectomy (PM) for metastatic sarcoma can result in long-term survival. The purpose of this study was to describe factors associated with survival in a series of patients undergoing PM for metastatic sarcoma.We reviewed all patients undergoing PM for metastatic sarcoma over a 12-year period (2000-2012). Multivariate analyses were used to identify factors associated with outcomes. Survival was calculated with Kaplan-Meier and Cox proportional hazard models.A total of 120 patients underwent PM with a median follow-up was 48 months. Among 81 (85%) patients who presented with local disease, the median disease free interval (DFI) was 13 months and median overall survival (OS) was 48 months. Fourteen patients (15%) had synchronous metastasis with a median OS of 21 months. On multivariate analysis, synchronous metastasis (P = 0.005), older age (P = 0.02), and number of lung lesions (P = 0.003) were associated with poor survival. The median OS of patients with a DFI ≥12 versus12 months following primary resection was 93 and 43 months (P = 0.004).While patients with a DFI12 months have the best OS following PM, patients with a DFI12 months also have excellent outcomes as compared to systemic therapy and should be considered for PM. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Plný text