Early recurrence in favorable stage II breast cancer--which approach is the best?
| Autor: | C, Diaconu, Camelia, Chifu, C, Cosman, Roxana, Livadariu, Irina, Florea, L, Miron, C, Dogaru |
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| Rok vydání: | 2011 |
| Předmět: |
Aged
80 and over Antineoplastic Agents Hormonal Biopsy Breast Neoplasms Middle Aged Survival Analysis Tamoxifen Cell Transformation Neoplastic Mastectomy Modified Radical Treatment Outcome Antineoplastic Combined Chemotherapy Protocols Biomarkers Tumor Humans Female Neoplasm Invasiveness Neoplasm Recurrence Local Aged Neoplasm Staging Retrospective Studies |
| Zdroj: | Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 114(3) |
| ISSN: | 0048-7848 |
| Popis: | Changing the sequence of therapeutic options in stage II breast cancer: first, a core biopsy, followed by the evaluation of the tumoral markers, adaptation of the chemotherapy scheme and finally, surgical approach. Thus would be possible to improve the hope of life in some stage II breast cancer patients, in whom survival is poorer than in some stage III patients.144 patients in stage II breast cancer were included in this study, over a period of 5 years (2000-2004). In all these patients the first therapeutic option was surgery (radically modified mastectomy type Madden), followed by systemic chemotherapy-FAC or FEC, 6 cycles, and finally Tamoxifen.34 out of them developed metastases in a period between 6 and 72 months, most of them in the first 26 months; 25 out of these 34 didn't have metastases in the axillary lymph nodes, and in 18 patients estrogen--and progesterone--receptors were highly positive. HER 2 neu was negative or low expressed in patients with metastases. CD 34 wasn't evaluate in the whole group.Early onset of metastases in the studied patients, in whom tumoral aggressiveness markers were not obvious, impose the evaluation of the angiogenesis markers and, when positive, chemotherapy as the first therapeutic option. |
| Databáze: | OpenAIRE |
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