Linkage disequilibrium between DNA markers at the low-density lipoprotein receptor gene

Autor:	R A, Hegele, R, Plaetke, J M, Lalouel
Rok vydání:	1990
Předmět:	Genetic Markers Chi-Square Distribution Restriction Mapping DNA Cosmids Linkage Disequilibrium Blotting Southern Gene Frequency Receptors LDL Data Interpretation Statistical Humans DNA Probes Chromosomes Human Pair 19 Alleles Polymorphism Restriction Fragment Length
Zdroj:	Genetic epidemiology. 7(1)
ISSN:	0741-0395
Popis:	We determined pairwise linkage disequilibria between 12 restriction fragment length polymorphism (RFLP) markers at or near the low-density lipoprotein receptor (LDLR) locus on chromosome 19p13.2-13.1 in 92 unrelated individuals. Of these 12 RFLPs, two were newly identified under a cosmid-based strategy designed to screen for RFLPs. We estimated linkage disequilibrium by determining three different measurements: D (the maximum likelihood estimate of linkage disequilibrium), D' (Lewontin's normalized estimate of D), and r (an index of gametic correlation). When r was used as the estimate of linkage disequilibrium, five of the 66 comparisons were significant according to a level of significance adjusted by the Bonferroni-Holm correction. Only four pairs of RFLPs within a 100 kb region that included the LDLR gene itself were in significant linkage disequilibrium. Although we were able to detect strong linkage disequilibrium between some pairs of RFLPs in this sample, most RFLPs at the LDLR locus were not in strong linkage disequilibrium despite their physical proximity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=pmid________::6ef62b4ec47ec08cd3325e2cad1a2cb3 https://pubmed.ncbi.nlm.nih.gov/1970320 Zobrazit plný text záznamu Plný text