Linkage studies with 17q and 18q markers in a breast/ovarian cancer family
| Autor: | Milner, B J, Allan, L A, Kelly, K F, Cruickshank, D, Hall, M, Johnston, A, Kitchener, H, Parkin, D, Haites, N |
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| Jazyk: | angličtina |
| Rok vydání: | 1993 |
| Předmět: |
Adult
Genetic Markers Male Genetic Linkage Breast Neoplasms Neoplastic Syndromes Hereditary Proto-Oncogenes Humans Genes Tumor Suppressor Genetic Predisposition to Disease Alleles Aged Family Health Ovarian Neoplasms Chromosome Mapping DNA Neoplasm Middle Aged Pedigree Blotting Southern Genes DCC Female Chromosome Deletion Lod Score Chromosomes Human Pair 18 Polymorphism Restriction Fragment Length Research Article Chromosomes Human Pair 17 |
| Popis: | Genes on chromosomes 17q and 18q have been shown to code for putative tumor suppressors. By a combination of allele-loss studies on sporadic ovarian carcinomas and linkage analysis on a breast/ovarian cancer family, we have investigated the involvement of such genes in these diseases. Allele loss occurred in sporadic tumors from both chromosome 17p, in 18/26 (69%) cases, and chromosome 17q, in 15/22 (68%) cases. In the three familial tumors studied, allele loss also occurred on chromosome 17 (in 2/3 cases for 17p markers and in 2/2 cases for a 17q allele). Allele loss on chromosome 18q, at the DCC (deleted in colorectal carcinomas) locus, was not as common (6/16 cases [38%]) in sporadic ovarian tumors but had occurred in all three familial tumors. The results of linkage analysis on the breast/ovarian cancer family suggested linkage between the disease locus and 17q markers, with a maximum lod score of 1.507 obtained with Mfd188 (D17S579) polymorphism at 5% recombination. The maximum lod score for DCC was 0.323 at 0.1% recombination. In this family our results are consistent with a predisposing gene for breast/ovarian cancer being located at chromosome 17q21. |
| Databáze: | OpenAIRE |
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