| Autor: |
Dodson, Andrew, Parry, Suzanne, Ibrahim, Merdol, Bartlett, John MS, Pinder, Sarah, Dowsett, Mitch, Miller, Keith |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
The Journal of Pathology: Clinical Research |
| ISSN: |
2056-4538 |
| Popis: |
We describe a collated data set of results from clinical testing of breast cancers carried out between 2009 and 2016 in the United Kingdom and Republic of Ireland. More than 199 000 patient biomarker data sets, together with clinicopathological parameters were collected. Our analyses focused on human epidermal growth factor receptor‐2 (HER2), oestrogen receptor (ER) and progesterone receptor (PR), with the aim of the study being to provide robust confirmatory evidence on known associations in these biomarkers and to uncover new data on previously undescribed or unconfirmed associations, thus strengthening the evidence‐base in clinical breast cancer testing. Overall, 13.1% of tumours were HER2‐positive; 10.6% in ER‐positive tumours, and 25.5% in ER‐negative tumours. Higher rates of HER2 positivity were significantly associated with patient age |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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