| Autor: |
F, Khasawneh, T, Osborne, P, Danaher, D, Barnes, C J, Chapman, J A, Stephenson, B, Singh |
| Rok vydání: |
2022 |
| Zdroj: |
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. |
| ISSN: |
1463-1318 |
| Popis: |
We look at the effect of introducing FIT in the straight-to-test (STT) two-week pathway for CIBH.FIT in primary care triages 2WW colorectal referrals for patients aged 60 years and above for STT Computed Tomography Colonography (CTC). We compare the impact of FIT in numbers of 2WW CTCs, in the year before and after FIT, in both CRC detection and cost-effectiveness at both 4 μg Hb/g faeces and 10 μg Hb/g faeces.At a threshold of 4 μg Hb/g faeces, the, PPV of FIT for diagnosis of CRC is 5.0% with a NPV 99.8% and PDR 25.5%. Introduction of FIT resulted in a reduction in the number of CTCs performed through the CIBH pathway from a mean of 143.9 per month prior to FIT to 66.8 CTCs per month once FIT was well established. Given a FIT threshold of 10 μg Hb/g the number of CTCs would be predicted to fall by 70.4 % to 42.6 CTCs per month resulting in higher CRC and PDR, and an estimated annual cost saving of £238 258 in our institution.FIT use in primary care improves the yield of 2WW referrals for CIBH alone and reduces burden and cost of investigations to exclude CRC. Improvements may be possible by increasing the cut off employed, without adversely affecting the risk of missing a cancer. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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