| Autor: |
M A, Spence, R S, Sparkes, J R, Heckenlively, J T, Pearlman, D, Zedalis, M, Sparkes, M, Crist, S, Tideman |
| Rok vydání: |
1977 |
| Předmět: |
|
| Zdroj: |
American journal of human genetics. 29(4) |
| ISSN: |
0002-9297 |
| Popis: |
A linkage analysis is reported for three branches of a single family segregating for autosomal dominant retinitis pigmentosa. A statistically significant lod score of 3.9 is obtained for the RP locus and AMY2 at a recombination frequency of 1%. This linkage indicates that the RP locus is on the no. 1 chromosome since the AMY2 locus has been placed on the short arm of 1. Lod scores are reported for four other loci on chromosome 1; none of these achieve statistical significance. Analyses are reported for 23 additional autosomal markers and close linkage with RP can be excluded for a number of these. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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