The Terpenoid Tetrahydroisoquinoline Alkaloids Emetine, Klugine, and Isocephaeline Inhibit the Activation of Hypoxia-Inducible Factor-1 (HIF-1) in Breast Tumor Cells
| Autor: | Zhou, Yu-Dong, Kim, Yong-Pil, Mohammed, Kaleem Asjad, Jones, Deborah K., Muhammad, Ilias, Dunbar, D. Chuck, Nagle, Dale G. |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Vascular Endothelial Growth Factor A
Molecular Structure Terpenes Emetine Nuclear Proteins Breast Neoplasms Rubiaceae Hypoxia-Inducible Factor 1 alpha Subunit Article DNA-Binding Proteins Alkaloids Tetrahydroisoquinolines Quinazolines Tumor Cells Cultured Humans Hypoxia-Inducible Factor 1 Transcription Factors |
| Popis: | Klugine (1), isocephaeline (2), and emetine (4) inhibited hypoxia-inducible factor-1 (HIF-1) activation by hypoxia in T47D breast tumor cells (IC(50) values 0.2, 1.1, and 0.11 muM, respectively). Compounds 1, 2, and 4 inhibited both hypoxia- and iron chelator-induced HIF-1 activation by blocking HIF-1alpha protein accumulation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|