Molecules That Cause or Prevent Parkinson's Disease
| Autor: | Shendelman, Shoshana, Jonason, Alan, Martinat, Cecile, Leete, Thomas, Abeliovich, Asa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Cytoplasm
Dopamine Genetic Vectors Protein Deglycase DJ-1 Synucleins Molecular Biology/Structural Biology Antioxidants Cell Line Tumor Humans Cysteine Neurons Oncogene Proteins Homozygote Intracellular Signaling Peptides and Proteins Cell Differentiation Parkinson Disease In Vitro Oxygen Oxidative Stress Spectrophotometry Mutation alpha-Synuclein Dimerization Oxidation-Reduction Research Article Neuroscience HeLa Cells Molecular Chaperones |
| Zdroj: | PLoS Biology |
| ISSN: | 1545-7885 1544-9173 |
| Popis: | Parkinson's disease (PD) pathology is characterized by the degeneration of midbrain dopamine neurons (DNs) ultimately leading to a progressive movement disorder in patients. The etiology of DN loss in sporadic PD is unknown, although it is hypothesized that aberrant protein aggregation and cellular oxidative stress may promote DN degeneration. Homozygous mutations in DJ-1 were recently described in two families with autosomal recessive inherited PD (Bonifati et al. 2003). In a companion article (Martinat et al. 2004), we show that mutations in DJ-1 alter the cellular response to oxidative stress and proteasomal inhibition. Here we show that DJ-1 functions as a redox-sensitive molecular chaperone that is activated in an oxidative cytoplasmic environment. We further demonstrate that DJ-1 chaperone activity in vivo extends to α-synuclein, a protein implicated in PD pathogenesis. The interaction of the proteins DJ-1 and α- synuclein described here may be important for understanding the molecular basis of Parkinson's disease |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|