| Autor: |
S R, Frenkel, B, Toolan, D, Menche, M I, Pitman, J M, Pachence |
| Rok vydání: |
1997 |
| Předmět: |
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| Zdroj: |
The Journal of bone and joint surgery. British volume. 79(5) |
| ISSN: |
0301-620X |
| Popis: |
We have developed a novel, two-layered, collagen matrix seeded with chondrocytes for repair of articular cartilage. It consists of a dense collagen layer which is in contact with bone and a porous matrix to support the seeded chondrocytes. The matrices were implanted in rabbit femoral trochleas for up to 24 weeks. The control groups received either a matrix without cells or no implant. The best histological repair was seen with cell-seeded implants. The permeability and glycosaminoglycan content of both implant groups were nearly normal, but were significantly less in tissue from empty defects. The type-II collagen content of the seeded implants was normal. For unseeded implants it was 74.3% of the normal and for empty defects only 20%. The current treatments for articular injury often result in a fibrous repair which deteriorates with time. This bilayer implant allowed sustained hyaline-like repair of articular defects during the entire six-month period of observation. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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