| Autor: |
E V, Markova, E Ya, Shevela, M A, Knyazeva, I V, Savkin, E V, Serenko, I M, Rashchupkin, T G, Amstislavskaya, A A, Ostanin, E R, Chernykh |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Bulletin of experimental biology and medicine. 172(3) |
| ISSN: |
1573-8221 |
| Popis: |
We studied the effect of soluble factors derived from human macrophages polarized to M2 phenotype under conditions of serum deprivation (M2-SF) on behavioral pattern and cytokine production in various brain structures in mice with modeled stress-induced depression. Intranasal administration of M2-SF for 7 days led to stimulation of locomotor and exploratory activities and a decrease in emotional reactivity in the open-field test as well as reduction in depression-like behavior in Porsolt forced swimming test and a decrease in anxiety and anhedonia. Correction of depression-like behavior was accompanied by down-regulation of proinflammatory cytokines (IL-1β, IL-6, TNFα, and IFNγ) in pathogenetically important brain structures (striatum, hippocampus, and frontal cortex). These data indicate that the antidepressant potential of M2 type macrophages can be mediated by the anti-inflammatory effects of M2-SF. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink